25 mg kg

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We aimed to identify predictive factors for insufficient Cmax in a population of critically ill patients. Methods: Prospective observational monocentric study of patients admitted to a general ICU and requiring a loading dose of amikacin. The amikacin Cmax was 69 [ When total body weight is used, low BMI tended to be associated with amikacin underdosing. These suggest the need for higher doses in patients with a positive h fluid balance in order to reach adequate therapeutic targets.

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RSS Link Copy. Full text links Cite Display options Display options. Comment in Amikacin dosing in the ICU: we now know more, but still not enough…. De Rosa FG, et al. Intensive Care Med. Epub May PMID: No abstract available. Similar articles Predictors of insufficient peak amikacin concentration in critically ill patients on extracorporeal membrane oxygenation.

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Crit Care. Standard dosing of amikacin and gentamicin in critically ill patients in variable and subtherapeutic concentrations. Roger C, et al. Int J Antimicrob Agents. Epub Mar PMID: Determinants of amikacin first peak concentration in critically ill patients. Boidin C, et al. Fundam Clin Pharmacol. Amikacin use and therapeutic drug monitoring in adults: do dose regimens and drug exposures affect either outcome or adverse events?

A systematic review. Jenkins A, et al. J Antimicrob Chemother. Epub Jul PMID: Review. Optimizing use of aminoglycosides in the critically ill. Rea RS, Capitano B. Rea RS, et al. Semin Respir Crit Care Med. See all similar articles. Cited by 36 articles Inhaled antibiotics during mechanical ventilation-why it will work. Desgrouas M, Ehrmann S. Desgrouas M, et al.

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Ann Transl Med. Ann Intensive Care. Hartman SJF, et al. Front Pharmacol. Pernod C, et al. Turk J Anaesthesiol Reanim. Epub Dec See all "Cited by" articles. References Crit Care Med. Publication types Observational Study Actions. MeSH terms Aged Actions. Body Mass Index Actions. Critical Illness Actions.

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Dose-Response Relationship, Drug Actions. Female Actions. Humans Actions. Infusions, Intravenous Actions. Injections Actions. Intensive Care Units Actions. Male Actions. Middle Aged Actions. Multivariate Analysis Actions.

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Prospective Studies Actions. Risk Factors Actions. Substances Anti-Bacterial Agents Actions. Amikacin Actions. Full text links [x] Springer. Copy Download.

25 mg kg

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Predictors of insufficient amikacin peak concentration in critically ill patients receiving a 25 mg/kg total body weight regimen